Download Microbicides for Prevention of HIV Infection by Jeremy Nuttall PDF

By Jeremy Nuttall

One of the main promising new techniques for the prevention of HIV transmission, fairly for constructing international locations, contains topical, self-administered items often called microbicides. the improvement of microbicides is an extended and complex procedure, and this quantity offers an outline of all of the serious parts, from the choice of acceptable candidate molecules and their formula, preclinical and medical trying out for protection and efficacy, recommendations for product registration and eventually, matters linked to product release, distribution and entry. The booklet will end up necessary to either these operating within the box and all others who're attracted to studying extra approximately this product classification, which has the aptitude to noticeably effect the way forward for this devastating epidemic.

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Microbicide products can be classified as coitally dependent or non-coitally dependent. Coitally dependent microbicides are applied immediately before and/or after intercourse, whereas coitally independent products are applied and provide sustained protection over time. During the past two decades, the majority of microbicide product development has focused on vaginally applied products. However, receptive anal intercourse (RAI) is practiced by both MSM and women around the world (Kalichman et al.

C. Rohan et al. 1 The History and Background of Polymeric Thin Films Thin polymeric films are solid dosage forms which consist of an active agent incorporated into a polymeric matrix. When applied to a mucosal surface the film disintegrates and releases the active drug agent. Oral thin films were first introduced in the 1970s. In 2001, Pfizer introduced the ListerineÒ Strip to freshen breath and by 2006, nine oral thin films were marketed worldwide. The initial thin films that were marketed were for consumer or cosmetic products.

2013). Women who utilized the film noted a lack of lubrication provided by the film but were less likely to report ‘‘messiness’’ as compared to that experienced with gel products (McGowan et al. 2013). Another study evaluating foaming tablets versus N-9 film for contraception over 28 weeks found that the film compared favorably in terms of acceptability to foam tablets. Several recent studies have been conducted to assess film acceptability. The first was the Product Acceptability Study (PAS II) Microbicide Dosage Forms 39 conducted by International Partnership for Microbicides which compared a tablet, film, and softgel placebo product (Nel et al.

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