Download Mapping of nervous system diseases via MicroRNAs by Christian Barbato, Francesca Ruberti PDF

By Christian Barbato, Francesca Ruberti

In fresh years, realizing of microRNA (miRNA) biogenesis, the molecular mechanisms during which miRNAs keep an eye on gene expression, and the practical roles of miRNAs has multiplied. Mapping of apprehensive approach ailments through MicroRNAs presents an updated evaluate at the functionality of miRNA in neurological illnesses in addition to developments in expertise for healing modulation of miRNA activity.

MicroRNAs are small RNA molecules that control gene expression post-transcriptionally. A turning out to be physique of facts means that miRNAs are dysregulated in numerous neurological issues. as well as reviewing normal ideas and novel insights on mind functionality in terms of miRNA, this publication additionally examines the function of miRNA in:

  • Neurological diseases
  • Neurodegenerative diseases
  • Neuropsychiatric diseases
  • Neurodevelopmental diseases

The ebook additionally discusses the importance of miRNAs as diagnostic instruments, biomarkers, brokers, and pursuits within the detection and remedy of neurological illnesses. each one bankruptcy comprises fabric concerning destiny diagnostic and healing advances.

Molecular and mobile neurobiological stories of miRNA-mediated gene silencing within the frightened approach have opened new frontiers for the improvement of recent diagnostic exams and genetic remedies for neurological illnesses. overlaying the complete diversity of appropriate options and giving a glance into current and destiny probabilities, Mapping of apprehensive process illnesses through MicroRNAs is an important state of the art reference for neurologists, neuropathologists, and researchers and practitioners in a variety of similar fields.

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Proc Natl Acad Sci USA 107:20382–7. Maiorano NA, Mallamaci A. 2009. Promotion of embryonic cortico-cerebral neuronogenesis by miR-124. Neural Dev 4:40. Makeyev EV, Zhang J, Carrasco MA, Maniatis T. 2007. The microRNAmiR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell 27:435–48. Meister G. 2013. Argonaute proteins: Functional insights and emerging roles. Nat Rev Genet 14:447–59. Michán S, Li Y, Chou MM, Parrella E, Ge H et al. 2010. SIRT1 is essential for normal cognitive function and synaptic plasticity.

Studies examining the role of miRNAs in the stress response have focused primarily on the role of miRNAs in the regulation of the GR, the effects of early-life stress on miRNAs, and the impact of various psychological stressors on miRNAs. Studies assessing the role of miRNAs in GR regulation indicate that miR-18 plays an important role in this process. Uchida et al. (2008), investigating the role of miRNAs in the stress response and vulnerability to repeated stress, were the first to demonstrate that GR mRNA translation is inhibited by miR-18a in vitro.

Interestingly, bioinformatic analysis revealed that miR-451 theoretically regulates genes involved in the CREB pathway and in GABAergic and cholinergic neurotransmission. The role of miRNAs in the mechanism of action of ketamine was further examined by Yang et al. (2014). 2); however, again there was very little overlap between the miRNAs identified in this study and that of O’Connor and colleagues. The authors went on to further investigate the role of one miRNA, miR-206. Ketamine downregulated levels of miR-206 both in vivo and in vitro leading to an upregulation of BDNF.

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