By F. A. Kincl, J. R. Pasqualini
Written through the world's best researchers in steroid biochemistry this quantity describes the ways that hormonal focus is regulated while pregnant. it's a complete account of ways biosynthesis, metabolism and inter-compartmental delivery are relating to the focus of every hormone present in placental, fetal and maternal cubicles. there's additionally an introductory bankruptcy on hormonal mechanism of motion
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Extra info for Production, Concentration and Metabolism During Pregnancy. Production, Concentration & Metabolism During Pregnancy
A Schematic Representation of Changes in the Endometrium During the Human Menstrual Cycle The endometrium stimulated by the two typical ovarian hormones (estrogens and progesterone) undergoes a cycle of proliferation, differentiation and desquamation (menstrual bleeding). The proliferative stage (follicular phase) is the period of regenerative activity. Mitosis are frequently seen, the epithelium becomes higher and more columnar and the glands become well developed and tortuous. The stroma cells of the superficial layer may become separated by edema fluid.
D i h y d r o p r o g e s t e r o n e , is v e r y l o w t h r o u g h o u t t h e cycle, 0 . , 1 9 6 8 ) . , 1 9 5 8 ) , b u t a t p r e s e n t , n o p h y s i o l o g i c a l role h a s b e e n f o u n d i n t h e h u m a n . T h e c o n c e n t r a t i o n of 5 a - p r e g n a n e d i o n e (5a-dihydroprogesterone) d u r i n g t h e follicular p h a s e is a r o u n d 5 t i m e s h i g h e r t h a n t h a t of p r o g e s t e r o n e , b u t d u r i n g t h e l u t e a l p h a s e , t h e v a l u e d e c r e a s e s t o 1 / 5 to 1 \1 of t h e p r o g e s t e r o n e c o n c e n t r a t i o n ( F i g .
P r o g e s t e r o n e g e n e r a t e s i n t e r m e d i a t e s w i t h a d o u b l e b o n d b e t w e e n C 4 a n d C 5 (4-ene pathway). T h i s p a t h w a y o c c u r s p r e f e r a b l y in t h e g r a n u l o s a cells a n d in t h e c o r p u s l u t e u m . H u m a n o v a r i a n p r o g e s t e r o n e c a n b e r e d u c e d t o 2 0 a - d i h y d r o p r o g e s t e r o n e a n d h y d r o x y l a t e d to 1 6 a - h y d r o x y p r o g e s t e r o n e . I n s o m e species this m e t a b o l i t e is t h o u g h t t o b e c o n v e r t e d i n t o estriol.