By Nadia Rosenthal, Richard P. Harvey
The improvement of the cardiovascular method is a swiftly advancing zone in biomedical examine, now coupled with the burgeoning box of cardiac regenerative drugs. A lucid knowing of those fields is paramount to decreasing human cardiovascular illnesses of either fetal and grownup foundation. major development can now be made via a accomplished research of embryonic improvement and its genetic regulate circuitry. center improvement and Regeneration, written by way of specialists within the box, offers crucial details on subject matters starting from the evolution and lineage origins of the constructing cardiovascular process to cardiac regenerative medication. A reference for clinicians, clinical researchers, scholars, and lecturers, this ebook deals large insurance of the latest advances. quantity One discusses middle evolution, contributing cellphone lineages; version platforms; cardiac development; morphology and asymmetry; middle patterning; epicardial, vascular, and lymphatic improvement; and congenital center ailments. quantity comprises chapters on transcription components and transcriptional regulate circuits in cardiac improvement and sickness; epigenetic modifiers together with microRNAs, genome-wide mutagenesis, imaging, and proteomics techniques; and the speculation and perform of stem cells and cardiac regeneration.Authored by means of international specialists in center improvement and sickness New learn on epigenetic modifiers in cardiac improvement entire assurance of stem cells and clients for cardiac regeneration up to date examine on transcriptional and proteomic circuits in cardiac sickness Full-color, certain illustrations
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Extra resources for Heart Development and Regeneration (2 Volume Set), Second Edition
These are the accessory pumps of crustaceans and insects, the branchial hearts of cephalopods and the lymph hearts of fish, amphibians and reptiles (Maynard, 1960; Romer, 1962; Satoh and Nitatori, 1980; Farrell, 1997; Pass, 2000). III. What is a heart? telling homology from analogy Our ability to expose and objectively discuss our ideas about the evolutionary origin of hearts depends largely on the meaning that we attach to the word. , “The American Heritage Dictionary of the English Language,” 2000; “Encyclopaedia Britannica,” 2006).
The chapters are written by the world’s experts and provide up-to-date reports from their laboratories, while treating the newcomer to a rich grounding in classical developmental biology of the cardiovascular system. These books together represent a comprehensive catalog of the individual parts of the whole as we currently know them. They relay current progress on compiling the instructions for putting the parts together in the context of how form and function are generated in the cardiovascular system to sustain life, and how these processes go awry in disease.
2006). Since any discussion on the evolutionary origins of hearts requires the tracing of lineage relationships between the various animal pumping organs, we argue that it is advisable to stick to concepts that convey the notion of homology rather than analogy. , they regress, merge into others, or divide into more compartments), Simoes-Costa et al. (2005) proposed that hearts can be defined as chambered pumps which, at some point in an animal’s lifetime, contain inflow and outflow segments that are invested with myocytes.