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By Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council, Commission on Life Sciences

Document of the Subcommittee on Reproductive and Developmental Toxicology of advised methods that may be used to guage chemical substances and actual brokers for his or her power to reason reproductive and developmental toxicology and the way those techniques can be utilized by means of the army. Softcover.

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Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

Record of the Subcommittee on Reproductive and Developmental Toxicology of instructed techniques that may be used to judge chemical compounds and actual brokers for his or her strength to reason reproductive and developmental toxicology and the way those techniques can be utilized via the army. Softcover.

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Extra info for Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

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The subcommittee was charged with the following tasks: • Develop a process for assessing the reproductive and developmental toxicity potential from exposures to chemicals and physical agents. • Develop a strategy for dealing with the potential reproductive and developmental toxicity of exposures to chemicals and physical agents for which little or no information is available. • Conduct pilot demonstrations on two chemicals using the process developed by the subcommittee. • Identify reliable sources for assessment of reproductive and developmental toxicity.

Concern regarding reproductive and developmental hazards in the workplace, including military facilities, has increased significantly in recent years. In 1997, Congress passed a law, as part of the National Defense Authorization Act, concerning health care coverage for children with medical conditions caused by parental exposure to hazardous materials while serving as members of the Armed Services (Public Law 104-201, Section 704). The law states, in part, that a plan would be developed for ensuring the provision of medical care to any natural child of a member of the Armed Forces who has a congenital defect or catastrophic illness, proven to a reasonable degree of scientific certainty on the basis of scientific research to have resulted from exposure of the member to a chemical warfare agent or other hazardous material to which the member was exposed during active military service.

This step involves combining information from the review of animal and human reproductive and developmental toxicity data with information from the review of general toxicity, pharmacokinetic, and exposure data. A weight-ofevidence approach is used to formulate judgments about potential hazards to humans. Three separate judgments should be developed: one each to address developmental toxicity, female reproductive toxicity, and male reproductive toxicity. Once an assessment has determined that the data indicate human risk potential for reproductive and developmental toxicity, the next step is to perform a quantitative evaluation.

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