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By Jeffrey C. Hall

The sector of genetics is quickly evolving and new scientific breakthroughs are happening due to advances in wisdom of genetics. This sequence constantly publishes vital stories of the broadest curiosity to geneticists and their colleagues in affiliated disciplines.

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Miller, K. , Kent, C. , Salenius, J. , Schmieder, F. , and Pilsudski, R. (2002). Naked plasmid DNA encoding fibroblast growth factor type 1 for the treatment of end‐stage unreconstructible lower extremity ischemia: Preliminary results of a phase I trial. J. Vasc. Surg. 35 (5), 930–936. Conry, R. , Curiel, D. , Strong, T. , Moore, S. , Allen, K. , Barlow, D. , Shaw, D. , and LoBuglio, A. F. (2002). Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients.

Le, T. , Hedstrom, R. , Coonan, K. , Jones, T. , Weiss, W. , Norman, J. , and Hoffman, S. L. (1998). Induction of antigen‐specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science 282(5388), 476–480. , Baraceros, F. , Gorak, E. , Carucci, D. , Hedstrom, R. , Jones, T. , Richie, T. , Parker, S. , Doolan, D. , and Hoffman, S. L. (2001). Induction of CD4(þ) T cell‐dependent CD8(þ) type 1 responses in humans by a malaria DNA vaccine. Proc. Natl. Acad. Sci. USA 98(19), 10817–10822.

MacGregor, R. , Ugen, K. , Kang, C. , Tu, X. , Weiner, D. , and Boyer, J. D. (2002). T‐cell responses induced in normal volunteers immunized with a DNA‐based vaccine containing HIV‐1 env and rev. AIDS 16(16), 2137–2143. , Ledwith, B. , Barnum, A. , Troilo, P. , Pauley, C. , Harper, L. , Griffiths, T. , Follmer, T. , Pacchione, S. , Beare, C. , Bagdon, W. , and Nichols, W. W. (2000). Plasmid DNA vaccines: Tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA.

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